Where are Toxoplasma gondii tachyzoites typically found in the blood?

Toxoplasma gondii tachyzoites are typically found intracellularly in nucleated cells. This is because tachyzoites are the rapidly dividing form of the parasite, and they invade host cells, particularly those of the immune system, such as macrophages and other nucleated cells. By residing within these cells, tachyzoites can evade the host immune response, which is critical for their survival and replication.

Freely circulating in plasma does not accurately describe the typical location of tachyzoites since they prefer to inhabit host cells rather than exist unattached in the bloodstream. While there may be brief periods when tachyzoites can be found in the blood, they are not primarily or typically found in that state.

Attachment to red blood cells is not a recognized behavior of Toxoplasma gondii. Instead, the parasite targets specific cells to facilitate its lifecycle and maintain its infectious potential.

Regarding the lymphatic system, while Toxoplasma gondii can affect components of the immune system there, tachyzoites are specifically not found just in the lymphatic system but rather within the cells that populate these areas. Thus, the intracellular location is the most critical aspect of their presence in relation to parasitic behavior.